The medicated scalp formulation, pharmacology and side effects

Development
Minca Scalp Spray is a compounded prescription medication. When the need arises we can design the spray to fit your individual circumstances. The spray, developed by Dr. Woodson, is based on his experience and current research and recommendations found in the peer reviewed published medical literature. He has used the spray clinically with success since 2009.

Formulation
Minca Scalp Spray includes a balance of prescription pharmaceuticals proven to have significant benefit in studies reported in the medical research literature for treatment of hair loss. Only one of the drugs included in the spray is US F.D.A. approved for treatment of hair loss in women and that is minoxidil. The other drugs are spironolactone, dutasteride, estradiol, and tretinoin that are used off-label for treatment of hair loss in women. Off-label use of pharmaceuticals is a common practice followed by most physicians that is permitted by the FDA as long as the drug is approved for another indication where it was found to be safe and effective.

Route of administration
One of the features of Minca Scalp Spray is that the drugs are all delivered to the hair follicle topically and in very small doses. By putting the drug where it is needed on the scalp allows the use of very low doses. To get the same effect taking the drug orally would require a dose 20 times greater.

Metabolism
Some of the applied drug is metabolized or broken down within the scalp itself. The portion absorbed by the scalp is small to begin with so there is not much to get into the systemic circulation. The active drug that does gain access to the blood does so slowly causing its concentration in the serum to be low. Once in the systemic circulation the liver is responsible for metabolizing the drugs in the spray, which it does rapidly. These factors explain why using these drugs topically on the scalp rather than by any other route of administration is desirable from both a clinical and safety prospective.

Side effects
Side effects with Minca Scalp Spray are rare. A few people’s scalp becomes irritated after using the spray, which goes away a few days after stopping it. The only serious potential side effect is the feminization of a male fetus that will occur if a pregnant female uses the spray. Under no circumstances should women planning to become pregnant within the next year or those currently pregnant use the spray of come into contact with it.

Anti-androgen actions of the medicated scalp spray

Of principal therapeutic importance in managing women with androgenic alopecia is to block harmful androgens from damaging the hair follicle. The androgen dihydrotestosterone (DHT) causes this damage. The other androgens including DHEA and testosterone are relatively harmless in those forms. They represent an implicit only because based entirely on the ability of the scalp to convert them into DHT.

Specifically DHT causes the follicle to shrivel up, become dormant and stop growing new hair. The spray includes three potent pharmaceuticals to accomplish this purpose using different but complementary pathways. Dutasteride is a potent inhibitor of an enzyme, 5 alpha reductase, found in the scalp and hair follicle, converts harmless testosterone into the very destructive DHT. This is included in the spray together with spironolactone, a pharmaceutical that blocks the ability of DHT gaining access to its nuclear receptor. These prevent circulating DHT produced elsewhere from being able to influence the hair cell. Another anti-androgen element is bioidentical estradiol. This hormone opposes the action of DHT in the cell defending the follicle against its devastating effects.

Anti-inflammatory actions of vitamins included in Minca Scalp Spray

Inflammation from any cause, whether it is local or systemic promotes hair loss. For instance a common local cause of scalp inflammation is seborrhea. This is the cause of dandruff and a flaky itchy scalp. It is caused by a fungus and is simply treated with medicated shampoo or topical gel. Many diseases and obesity are also sources of systemic inflammation that can affect the hair follicle by raising the blood level of inflammatory proteins activity of killer t-cells and macrophages. These enter the scalp and attack the hair follicle, which in this case is simply an innocent bystander falling victim to these insults.

In nature vitamin A is converted into tretinoin that the body uses in many ways with one of the most important being reducing and controlling the inflammation. A small dose of bioidentical tretinoin has been included in the Minca Scalp Spray formula for this purpose.

Vitamin D is also included in the spray. When activated by the scalp cells Vitamin D acts at the nucleus of the cell to control immune cells. It exerts positive control over immature immune cells that are active within the scalp causing damage. The calming effect of vitamin D on these cells reduces their release of inflammatory chemicals into the scalp. The upshot is control of inappropriate inflammation without the inhibition of an appropriate immune response to a real invading virus, bacterium or aberrant mutated skin cell.

Vitamin E is used in the spray to preserve the other drugs and as an antioxidant. It reduces the effect of metabolic byproducts produced in the scalp that cause inflammation and damage to the DNA of the hair stem cells.